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Semaglutide: Uses, Safety and Prescription Information

The active ingredient in Wegovy, Ozempic and Rybelsus – what it is, its authorised uses and why professional assessment matters.

Published 20 October 2026 · Last reviewed 20 October 2026 · Editorial content by the Peptide Atelier UK team, not clinically reviewed

Editorial standards and corrections

Educational information only. Semaglutide is a prescription-only medicine. Peptide Atelier UK does not sell, supply or prescribe it. This page is not medical advice; speak to a GP, pharmacist or other qualified healthcare professional.

What is semaglutide?

Semaglutide is a GLP-1 (glucagon-like peptide-1) receptor agonist. It mimics a naturally occurring hormone involved in regulating blood glucose and appetite.

Semaglutide-containing medicines in the UK

These products contain the same active ingredient but are authorised for different uses, at different doses. One cannot simply be swapped for another. Always refer to the official product information for current authorised indications.

Ozempic – a weekly injection authorised for adults with type 2 diabetes.
Rybelsus – a daily tablet authorised for adults with type 2 diabetes.
Wegovy – a weekly injection authorised for weight management in specific adults alongside diet and physical activity, and for reducing cardiovascular risk in certain patients.

General safety considerations

Common side effects include nausea, vomiting, diarrhoea, constipation and abdominal pain. Less common but serious risks described in the product information include pancreatitis and gallbladder problems. Semaglutide is not recommended during pregnancy. This is not a complete list – the patient information leaflet and your prescriber are the authoritative sources.

Prescription requirements

Semaglutide is a prescription-only medicine. A prescriber must assess whether it is clinically appropriate, considering your medical history, other medicines and eligibility criteria. In England, NHS access to Wegovy for weight management follows NICE guidance, often through specialist weight management services.

Avoiding fake products

The MHRA has warned about counterfeit and unlicensed semaglutide pens sold online. Never buy semaglutide without a prescription or from sellers who are not registered pharmacies.